Progress in antiandrogen design targeting hormone binding pocket to circumvent mutation based resistance

Androgen receptor (AR) plays a critical role in the development and progression of prostate cancer (PCa). Current clinically used antiandrogens such as flutamide, bicalutamide, and newly approved enzalutamide mainly target the hormone binding pocket (HBP) of AR. However, over time, drug resistance i...

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Bibliographic Details
Main Authors: Xiaohong eTian (Author), Yang eHe (Author), Jinming eZhou (Author)
Format: Book
Published: Frontiers Media S.A., 2015-03-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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