Predicting In Vivo Efficacy from In Vitro Data: Quantitative Systems Pharmacology Modeling for an Epigenetic Modifier Drug in Cancer

• Main Authors: Mehdi Bouhaddou (Author), Li J. Yu (Author), Serena Lunardi (Author), Spyros K. Stamatelos (Author), Fiona Mack (Author), James M. Gallo (Author), Marc R. Birtwistle (Author), Antje‐Christine Walz (Author)
• Format: Book
• Published: Wiley, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Reliably predicting in vivo efficacy from in vitro data would facilitate drug development by reducing animal usage and guiding drug dosing in human clinical trials. However, such prediction remains challenging. Here, we built a quantitative pharmacokinetic/pharmacodynamic (PK/PD) mathematical model...