SAL0114: a novel deuterated dextromethorphan-bupropion combination with improved antidepressant efficacy and safety profile

• Main Authors: Ying Xiao (Author), Xuefeng Hu (Author), Wei Xing (Author), Jie Yan (Author), Ruhuan Wang (Author), Xiaoqing Li (Author), Jiahuan Li (Author), Zhixin Zhang (Author), Jingchao Sun (Author), Junjun Wu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundEsketamine, the first Food and Drug Administration-approved fast-acting antidepressant, has limited use because of its addictive properties. Although the combination of dextromethorphan and bupropion partially addresses the limitations of esketamine, concerns remain regarding neurologic si...