Osteopontin activity modulates sex‐specific calcification in engineered valve tissue mimics

• Main Authors: Megan E. Schroeder (Author), Dilara Batan (Author), Andrea Gonzalez Rodriguez (Author), Kelly F. Speckl (Author), Douglas K. Peters (Author), Bruce E. Kirkpatrick (Author), Grace K. Hach (Author), Cierra J. Walker (Author), Joseph C. Grim (Author), Brian A. Aguado (Author), Robert M. Weiss (Author), Kristi S. Anseth (Author)
• Format: Book
• Published: Wiley, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Patients with aortic valve stenosis (AVS) have sexually dimorphic phenotypes in their valve tissue, where male valvular tissue adopts a calcified phenotype and female tissue becomes more fibrotic. The molecular mechanisms that regulate sex‐specific calcification in valvular tissue remain po...