Assessment of H3K27me3 immunohistochemistry and combination of NF1 and p16 deletions by fluorescence in situ hybridization in the differential diagnosis of malignant peripheral nerve sheath tumor and its histological mimics

• Main Authors: Shintaro Sugita (Author), Tomoyuki Aoyama (Author), Makoto Emori (Author), Tomomi Kido (Author), Tomoko Takenami (Author), Kodai Sakuraba (Author), Kotomi Terai (Author), Taro Sugawara (Author), Mitsuhiro Tsujiwaki (Author), Tadashi Hasegawa (Author)
• Format: Book
• Published: BMC, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background A definitive diagnosis of malignant peripheral nerve sheath tumor (MPNST) is challenging, especially in cases without neurofibromatosis 1 (NF1), because MPNST lacks specific markers on immunohistochemistry (IHC). Methods We performed IHC for histone 3 trimethylated on lysine 27 (...