Insulin-like growth factor 2 promotes osteoclastogenesis increasing inflammatory cytokine levels under hypoxia

• Main Authors: Takao Kondo (Author), Hiromasa Aoki (Author), Yuto Otsuka (Author), Yohei Kawaguchi (Author), Yuko Waguri-Nagaya (Author), Mineyoshi Aoyama (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteoporosis is caused by an imbalance in bone remodeling due to abnormal osteoclast (OC) formation and activation. Hypoxia at the site of inflammation promotes OC formation and activation in various species, including humans. We previously reported that insulin-like growth factor 2 (IGF2) plays an...