Evaluation of the relationship between polymorphisms in CYP2C19 and the single‐dose pharmacokinetics of omeprazole in healthy Chinese volunteers: A multicenter study

• Main Authors: Shuang Zhou (Author), Ran Xie (Author), Xiaodan Zhang (Author), Xu He (Author), Jie Huang (Author), Yin Jungang (Author), Man Liao (Author), Ying Ding (Author), Dandan Yang (Author), Ying Liu (Author), Qian Zhang (Author), Guoping Yang (Author), Fang Liu (Author), Shengjiang Guan (Author), Qing He (Author), Honggang Lou (Author), Fengyun Gong (Author), Xianmin Meng (Author), Qian Xiang (Author), Xia Zhao (Author), Yimin Cui (Author)
• Format: Book
• Published: Wiley, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The aim of this study was to evaluate the relationship between polymorphisms in CYP2C19 and the single‐dose pharmacokinetics (PKs) of omeprazole in healthy Chinese volunteers. A 20 mg single dose of omeprazole (Losec) enteric‐coated capsules or tablets was orally administered to 656 healthy...