An Integrated In Silico and In Vivo Approach to Identify Protective Effects of Palonosetron in Cisplatin-Induced Nephrotoxicity

• Main Authors: Eri Wakai (Author), Yuya Suzumura (Author), Kenji Ikemura (Author), Toshiro Mizuno (Author), Masatoshi Watanabe (Author), Kazuhiko Takeuchi (Author), Yuhei Nishimura (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cisplatin is widely used to treat various types of cancers, but it is often limited by nephrotoxicity. Here, we employed an integrated in silico and in vivo approach to identify potential treatments for cisplatin-induced nephrotoxicity (CIN). Using publicly available mouse kidney and human kidney or...