Letrozole protects against cadmium-induced inhibition of spermatogenesis via LHCGR and Hsd3b6 to activate testosterone synthesis in mice

• Main Authors: Yao Yao (Author), Yangyang Wan (Author), Xiaoyun Shi (Author), Lan Guo (Author), Hui Jiang (Author), Xiansheng Zhang (Author), Bo Xu (Author), Juan Hua (Author)
• Format: Book
• Published: BMC, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The heavy metal cadmium is proposed to be one of the environmental endocrine disruptors of spermatogenesis. Cadmium-induced inhibition of spermatogenesis is associated with a hormone secretion disorder. Letrozole is an aromatase inhibitor that increases peripheral androgen levels and stimul...