Notch signaling deficiency underlies age-dependent depletion of satellite cells in muscular dystrophy

• Main Authors: Chunhui Jiang (Author), Yefei Wen (Author), Kazuki Kuroda (Author), Kevin Hannon (Author), Michael A. Rudnicki (Author), Shihuan Kuang (Author)
• Format: Book
• Published: The Company of Biologists, 2014-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Duchenne muscular dystrophy (DMD) is a devastating disease characterized by muscle wasting, loss of mobility and death in early adulthood. Satellite cells are muscle-resident stem cells responsible for the repair and regeneration of damaged muscles. One pathological feature of DMD is the progressive...