Sorafenib-loaded nanostructured lipid carriers for topical ocular therapy of corneal neovascularization: development, in-vitro and in vivo study

• Main Authors: Qing Luo (Author), Jingjing Yang (Author), Haohang Xu (Author), Jieran Shi (Author), Zhen Liang (Author), Rui Zhang (Author), Ping Lu (Author), Guojuan Pu (Author), Ningmin Zhao (Author), Junjie Zhang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sorafenib (SRB), a multikinase inhibitor, is effective in reducing experimental corneal neovascularization (CNV) after oral administration; however, its therapeutic use in ocular surface disorders is restricted due to poor solubility and limited bioavailability. This study aimed to develop and optim...