Intestinal Metabolism of Crocin and a Pharmacokinetics and Pharmacodynamics Study in the Chronic Social Defeat Stress Mouse Model

• المؤلفون الرئيسيون: Fan Xiao (مؤلف), Yulong Song (مؤلف), Guangji Wang (مؤلف), Jiye Aa (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2024-06-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Orally administered crocin rapidly and efficiently rescues depressive-like behaviors in depression models; however, crocin levels in the circulatory and central nervous systems are rather low. The underlying mechanism responsible for the inconsistency between pharmacokinetics and pharmacodynamics is...