Role of sigma-1 receptors in neurodegenerative diseases

• Main Authors: Linda Nguyen (Author), Brandon P. Lucke-Wold (Author), Shona A. Mookerjee (Author), John Z. Cavendish (Author), Matthew J. Robson (Author), Anna L. Scandinaro (Author), Rae R. Matsumoto (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neurodegenerative diseases with distinct genetic etiologies and pathological phenotypes appear to share common mechanisms of neuronal cellular dysfunction, including excitotoxicity, calcium dysregulation, oxidative damage, ER stress and mitochondrial dysfunction. Glial cells, including microglia and...