JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis

• Main Authors: Chihiro Okuma (Author), Takeshi Ohta (Author), Hironobu Tadaki (Author), Tatsuya Ishigure (Author), Shohei Sakata (Author), Hideyuki Taniuchi (Author), Ryuhei Sano (Author), Hiromi Hamada (Author), Shinichi Kume (Author), Jun Nishiu (Author), Makoto Kakutani (Author)
• Format: Book
• Published: Elsevier, 2015-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: Monoacyglycerol acyltransferases (MGATs) are known to play important roles in intestinal TG absorption. In contrast, the role of MGATs in the liver is still unclear. We investigated the effects of JTP-103237, a novel MGAT inhibitor, on hepatic MGAT activity and hepatic lipid metabolism. Results...