JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis

• मुख्य लेखकों: Chihiro Okuma (लेखक), Takeshi Ohta (लेखक), Hironobu Tadaki (लेखक), Tatsuya Ishigure (लेखक), Shohei Sakata (लेखक), Hideyuki Taniuchi (लेखक), Ryuhei Sano (लेखक), Hiromi Hamada (लेखक), Shinichi Kume (लेखक), Jun Nishiu (लेखक), Makoto Kakutani (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2015-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Aim: Monoacyglycerol acyltransferases (MGATs) are known to play important roles in intestinal TG absorption. In contrast, the role of MGATs in the liver is still unclear. We investigated the effects of JTP-103237, a novel MGAT inhibitor, on hepatic MGAT activity and hepatic lipid metabolism. Results...