miR675 Accelerates Malignant Transformation of Mesenchymal Stem Cells by Blocking DNA Mismatch Repair

• Main Authors: Yanan Lu (Author), Shuting Song (Author), Xiaoxue Jiang (Author), Qiuyu Meng (Author), Chen Wang (Author), Xiaonan Li (Author), Yuxin Yang (Author), Xiaoru Xin (Author), Qidi Zheng (Author), Liyan Wang (Author), Hu Pu (Author), Xin Gui (Author), Tianming Li (Author), Dongdong Lu (Author)
• 格式: 图书
• 出版: Elsevier, 2019-03-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

miR675 is highly expressed in several human tumor tissues and positively regulates cell progression. Herein, we demonstrate that miR675 promotes malignant transformation of human mesenchymal stem cells. Mechanistically, we reveal that miR675 enhances the expression of the polyubiquitin-binding prote...