A novel immune checkpoint siglec-15 antibody inhibits LUAD by modulating mφ polarization in TME
Background: Siglec-15 (S15) is a type-I transmembrane protein and is considered a new candidate of immune checkpoint inhibitor for cancer immunotherapy. Methods: In the present study, we first constructed and characterized a chimeric S15-specific monoclonal antibody (S15-4E6A). Then, the antitumor e...
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Formaat: | Boek |
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Elsevier,
2022-07-01T00:00:00Z.
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Internet
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A1234.567 |
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Kopie 1 | Beschikbaar |