A novel immune checkpoint siglec-15 antibody inhibits LUAD by modulating mφ polarization in TME

• Main Authors: Xuejun Xiao (Author), Yan Peng (Author), Zheyue Wang (Author), Louqian Zhang (Author), Tingting Yang (Author), Yangyang Sun (Author), Yufeng Chen (Author), Wenqing Zhang (Author), Xinxia Chang (Author), Wen Huang (Author), Shuning Tian (Author), Zhenqing Feng (Author), Nabi Xinhua (Author), Qi Tang (Author), Yuan Mao (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Siglec-15 (S15) is a type-I transmembrane protein and is considered a new candidate of immune checkpoint inhibitor for cancer immunotherapy. Methods: In the present study, we first constructed and characterized a chimeric S15-specific monoclonal antibody (S15-4E6A). Then, the antitumor e...