A serine protease inhibitor attenuates aldosterone-induced kidney injuries via the suppression of plasmin activity

• Main Authors: Yutaka Kakizoe (Author), Yoshikazu Miyasato (Author), Tomoaki Onoue (Author), Terumasa Nakagawa (Author), Manabu Hayata (Author), Kohei Uchimura (Author), Jun Morinaga (Author), Teruhiko Mizumoto (Author), Masataka Adachi (Author), Taku Miyoshi (Author), Yoshiki Sakai (Author), Kimio Tomita (Author), Masashi Mukoyama (Author), Kenichiro Kitamura (Author)
• Format: Book
• Published: Elsevier, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Emerging evidence has suggested that aldosterone has direct deleterious effects on the kidney independently of its hemodynamic effects. However, the detailed mechanisms of these direct effects remain to be elucidated. We have previously reported that camostat mesilate (CM), a synthetic serine protea...