Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice

• Main Authors: Omar Mamad (Author), Mona Heiland (Author), Andreas U. Lindner (Author), Thomas D. M. Hill (Author), Ronan M. Ronroy (Author), Kilian Rentrup (Author), Amaya Sanz-Rodriguez (Author), Elena Langa (Author), Janosch P. Heller (Author), Oscar Moreno (Author), Jordi Llop (Author), Anindya Bhattacharya (Author), James A. Palmer (Author), Marc Ceusters (Author), Tobias Engel (Author), David C. Henshall (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There remains a need for new drug targets for treatment-resistant temporal lobe epilepsy. The ATP-gated P2X7 receptor coordinates neuroinflammatory responses to tissue injury. Previous studies in mice reported that the P2X7 receptor antagonist JNJ-47965567 suppressed spontaneous seizures in the intr...