Reduced activity of adenylyl cyclase 1 attenuates morphine induced hyperalgesia and inflammatory pain in mice

• Main Authors: Kayla Johnson (Author), Alexis Doucette (Author), Alexis Edwards (Author), Aleeya Verdi (Author), Ryan McFarland (Author), Shelby Hulke (Author), Amanda Fowler (Author), Val J. Watts (Author), Amanda H. Klein (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Opioid tolerance, opioid-induced hyperalgesia during repeated opioid administration, and chronic pain are associated with upregulation of adenylyl cyclase activity. The objective of this study was to test the hypothesis that a reduction in adenylyl cyclase 1 (AC1) activity or expression would attenu...