Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study

• Main Authors: Alan K. Jarmusch (Author), Alison Vrbanac (Author), Jeremiah D. Momper (Author), Joseph D. Ma (Author), Maher Alhaja (Author), Marlon Liyanage (Author), Rob Knight (Author), Pieter C. Dorrestein (Author), Shirley M. Tsunoda (Author)
• Format: Book
• Published: Wiley, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Determining factors that contribute to interindividual and intra‐individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans. Intestinal microbes are important contributors to variability; however, such gut microbe‐drug interactions and th...