Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway

• Main Authors: Yejin Xu (Author), Xinyue Tang (Author), Min Yang (Author), Shengguo Zhang (Author), Shanshan Li (Author), Yukai Chen (Author), Minhui Liu (Author), Yuxiang Guo (Author), Mingqin Lu (Author)
• 格式: 图书
• 出版: Hindawi Limited, 2019-01-01T00:00:00Z.
• 主题: article
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Aim. To explore the therapeutic effects and mechanisms of interleukin 10 gene-modified bone marrow-derived dendritic cells (DC-IL10) on liver fibrosis. Methods. In vitro, BMDCs were transfected with lentiviral-interleukin 10-GFP (LV-IL10-GFP) at the MOI of 1 : 40. Then, the phenotype (MHCII, CD80, a...