Identification of Antagonistic Action of Pyrrolizidine Alkaloids in Muscarinic Acetylcholine Receptor M1 by Computational Target Prediction Analysis

• Main Authors: Sara Abdalfattah (Author), Caroline Knorz (Author), Akhtar Ayoobi (Author), Ejlal A. Omer (Author), Matteo Rosellini (Author), Max Riedl (Author), Christian Meesters (Author), Thomas Efferth (Author)
• Format: Book
• Published: MDPI AG, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pyrrolizidine alkaloids (PAs) are one of the largest distributed classes of toxins in nature. They have a wide range of toxicity, such as hepatotoxicity, pulmonary toxicity, neuronal toxicity, and carcinogenesis. Yet, biological targets responsible for these effects are not well addressed. Using met...