Atrial-selective block of sodium channels by acehytisine in rabbit myocardium

• Main Authors: Xinrong Fan (Author), Chao Wang (Author), Na Wang (Author), Xianhong Ou (Author), Hanxiong Liu (Author), Yan Yang (Author), Xitong Dang (Author), Xiaorong Zeng (Author), Lin Cai (Author)
• Format: Book
• Published: Elsevier, 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acehytisine, a multi-ion channel blocker, can markedly inhibit INa, ICa, IKur, If at various concentrations and effectively terminate and prevent atrial fibrillation (AF) in patients and animal models, but the molecular mechanism underlying its blockage remains elusive. In this study, we investigate...