Comparative pharmacokinetics of tetramethylpyrazine phosphate in rat plasma and extracellular fluid of brain after intranasal, intragastric and intravenous administration

• Main Authors: Dongmei Meng (Author), Haoyang Lu (Author), Shanshan Huang (Author), Minyan Wei (Author), Pingtian Ding (Author), Xianglin Xiao (Author), Yuehong Xu (Author), Chuanbin Wu (Author)
• Formato: Livro
• Publicado em: Elsevier, 2014-02-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The purpose of this study was to compare the pharmacokinetic profiles of tetramethylpyrazine phosphate (TMPP) in plasma and extracellular fluid of the cerebral cortex of rats via three delivery routes: intranasal (i.n.), intragastric (i.g.) and intravenous (i.v.) administration. After i.n., i.g. and...