Morphine induces endocytosis of neuronal μ-opioid receptors through the sustained transfer of Gα subunits to RGSZ2 proteins

• Main Authors: Garzón Javier (Author), Sánchez-Blázquez Pilar (Author), de la Torre-Madrid Elena (Author), Rodríguez-Muñoz María (Author)
• Format: Book
• Published: SAGE Publishing, 2007-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>In general, opioids that induce the recycling of μ-opioid receptors (MORs) promote little desensitization, although morphine is one exception to this rule. While morphine fails to provoke significant internalization of MORs in cultur...