Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases.

• Main Authors: Ross A Paveley (Author), Nuha R Mansour (Author), Irene Hallyburton (Author), Leo S Bleicher (Author), Alex E Benn (Author), Ivana Mikic (Author), Alessandra Guidi (Author), Ian H Gilbert (Author), Andrew L Hopkins (Author), Quentin D Bickle (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sole reliance on one drug, Praziquantel, for treatment and control of schistosomiasis raises concerns about development of widespread resistance, prompting renewed interest in the discovery of new anthelmintics. To discover new leads we designed an automated label-free, high content-based, high thro...