Potential for Isolation of Immortalized Hepatocyte Cell Lines by Liver-Directed In Vivo Gene Delivery of Transposons in Mice

• Main Authors: Masahiro Sato (Author), Issei Saitoh (Author), Emi Inada (Author), Shingo Nakamura (Author), Satoshi Watanabe (Author)
• Format: Knjiga
• Izdano: Hindawi Limited, 2019-01-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Isolation of hepatocytes and their culture in vitro represent important avenues to explore the function of such cells. However, these studies are often difficult to perform because of the inability of hepatocytes to proliferate in vitro. Immortalization of isolated hepatocytes is thus an important s...