Tumor growth inhibition modeling to support the starting dose for dacomitinib

Abstract Dacomitinib is a second‐generation, irreversible EGFR tyrosine kinase inhibitor for first‐line treatment of patients with metastatic non‐small cell lung cancer and EGFR‐activating mutations. A high rate of dose reductions in the pivotal trial led to an observed inverse exposure‐response (ER...

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Main Authors: Luke K. Fostvedt (Author), Dana J. Nickens (Author), Weiwei Tan (Author), Kourosh Parivar (Author)
Format: Book
Published: Wiley, 2022-09-01T00:00:00Z.
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3rd Floor Main Library

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