Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism.

• Główni autorzy: Simone Pieretti (Autor), Jurgen R Haanstra (Autor), Muriel Mazet (Autor), Remo Perozzo (Autor), Christian Bergamini (Autor), Federica Prati (Autor), Romana Fato (Autor), Giorgio Lenaz (Autor), Giovanni Capranico (Autor), Reto Brun (Autor), Barbara M Bakker (Autor), Paul A M Michels (Autor), Leonardo Scapozza (Autor), Maria Laura Bolognesi (Autor), Andrea Cavalli (Autor)
• Format: Książka
• Wydane: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

BACKGROUND AND METHODOLOGY: Recently, we reported on a new class of naphthoquinone derivatives showing a promising anti-trypanosomatid profile in cell-based experiments. The lead of this series (B6, 2-phenoxy-1,4-naphthoquinone) showed an ED(50) of 80 nM against Trypanosoma brucei rhodesiense, and a...