Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism.

Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism.

BACKGROUND AND METHODOLOGY: Recently, we reported on a new class of naphthoquinone derivatives showing a promising anti-trypanosomatid profile in cell-based experiments. The lead of this series (B6, 2-phenoxy-1,4-naphthoquinone) showed an ED(50) of 80 nM against Trypanosoma brucei rhodesiense, and a...

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Main Authors: Simone Pieretti (Author), Jurgen R Haanstra (Author), Muriel Mazet (Author), Remo Perozzo (Author), Christian Bergamini (Author), Federica Prati (Author), Romana Fato (Author), Giorgio Lenaz (Author), Giovanni Capranico (Author), Reto Brun (Author), Barbara M Bakker (Author), Paul A M Michels (Author), Leonardo Scapozza (Author), Maria Laura Bolognesi (Author), Andrea Cavalli (Author)
Format: Book
Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
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