Amlexanox: Readthrough Induction and Nonsense-Mediated mRNA Decay Inhibition in a Charcot-Marie-Tooth Model of hiPSCs-Derived Neuronal Cells Harboring a Nonsense Mutation in <i>GDAP1</i> Gene

Amlexanox: Readthrough Induction and Nonsense-Mediated mRNA Decay Inhibition in a Charcot-Marie-Tooth Model of hiPSCs-Derived Neuronal Cells Harboring a Nonsense Mutation in <i>GDAP1</i> Gene

Nonsense mutations are involved in multiple peripheral neuropathies. These mutations induce the presence of a premature termination codon (PTC) at the mRNA level. As a result, a dysfunctional or truncated protein is synthesized, or even absent linked to nonsense-mediated mRNA degradation (NMD) syste...

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Main Authors: Nesrine Benslimane (Author), Federica Miressi (Author), Camille Loret (Author), Laurence Richard (Author), Angélique Nizou (Author), Ioanna Pyromali (Author), Pierre-Antoine Faye (Author), Frédéric Favreau (Author), Fabrice Lejeune (Author), Anne-Sophie Lia (Author)
Format: Book
Published: MDPI AG, 2023-07-01T00:00:00Z.
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3rd Floor Main Library

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