G-Quadruplex-Forming DNA Aptamers Inhibit the DNA-Binding Function of HupB and Mycobacterium tuberculosis Entry into Host Cells

• Main Authors: Priya Kalra (Author), Subodh Kumar Mishra (Author), Surinder Kaur (Author), Amit Kumar (Author), Hanumanthappa Krishna Prasad (Author), Tarun Kumar Sharma (Author), Jaya Sivaswami Tyagi (Author)
• Format: Book
• Published: Elsevier, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The entry and survival of Mycobacterium tuberculosis (Mtb) within host cells is orchestrated partly by an essential histone-like protein HupB (Rv2986c). Despite being an essential drug target, the lack of structural information has impeded the development of inhibitors targeting the indispensable an...