Design, synthesis and SAR studies of novel tacrine derivatives as potent cholinesterase inhibitors

• Autores principales: Bhushanarao Dogga (Autor), Eeda Koti Reddy (Autor), C.S. Sharanya (Autor), J. Abhithaj (Autor), K.G. Arun (Autor), C.S. Ananda Kumar (Autor), K.S. Rangappa (Autor)
• Formato: Libro
• Publicado: Elsevier, 2022-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

A series of tacrine-2-amide derivatives were synthesized and biologically evaluated for their acetylcholinesterase (AChE) inhibition studies. All synthesized compounds showed a good potency less than 100 ​nM. Of 11 analogues compounds 7b, 8a and 8c were found to exhibit good potency of 23.66 ​nM, 20...