Design, synthesis and SAR studies of novel tacrine derivatives as potent cholinesterase inhibitors

• Main Authors: Bhushanarao Dogga (Author), Eeda Koti Reddy (Author), C.S. Sharanya (Author), J. Abhithaj (Author), K.G. Arun (Author), C.S. Ananda Kumar (Author), K.S. Rangappa (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of tacrine-2-amide derivatives were synthesized and biologically evaluated for their acetylcholinesterase (AChE) inhibition studies. All synthesized compounds showed a good potency less than 100 ​nM. Of 11 analogues compounds 7b, 8a and 8c were found to exhibit good potency of 23.66 ​nM, 20...