Microbial metabolite deoxycholic acid-mediated ferroptosis exacerbates high-fat diet-induced colonic inflammation

• Main Authors: Chen Wang (Author), Qiao Chu (Author), Wenxiao Dong (Author), Xin Wang (Author), Wenjing Zhao (Author), Xin Dai (Author), Wentian Liu (Author), Bangmao Wang (Author), Tianyu Liu (Author), Weilong Zhong (Author), Changtao Jiang (Author), Hailong Cao (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

High-fat diet (HFD) has long been recognized as risk factors for the development and progression of ulcerative colitis (UC), but the exact mechanism remained elusive. Here, HFD increased intestinal deoxycholic acid (DCA) levels, and DCA further exacerbated colonic inflammation. Transcriptome analysi...