Hyaluronic acid-enriched bilosomes: an approach to enhance ocular delivery of agomelatine via D-optimal design: formulation, in vitro characterization, and in vivo pharmacodynamic evaluation in rabbits

• Main Authors: Asmaa Ashraf Nemr (Author), Galal Mohamed El-Mahrouk (Author), Hany Abdo Badie (Author)
• פורמט: ספר
• יצא לאור: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Agomelatine (AGO) is a dual-functional drug. It uses as an antidepressant when orally administrated and antiglaucomic when topically applied to the eye. This study aimed to formulate AGO into bilosomal vesicles for glaucoma treatment, as modern studies pointed out the effect of topical AGO on intrao...