Possible Involvement of Endogenous Opioid System Located Downstream of α7 Nicotinic Acetylcholine Receptor in Mice With Physical Dependence on Nicotine

• Main Authors: Keiko Ueno (Author), Norikazu Kiguchi (Author), Yuka Kobayashi (Author), Fumihiro Saika (Author), Naoki Wakida (Author), Chizuko Yamamoto (Author), Takehiko Maeda (Author), Masanobu Ozaki (Author), Shiroh Kishioka (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: We previously reported that nicotine (NIC)-induced analgesia was elicited in part by activation of the endogenous opioid system. Moreover, it is well known that NIC has physical-dependence liability, but its mechanism is unclear. Therefore, we examined whether physical dependence on NIC w...