Nobiletin and its derivatives overcome multidrug resistance (MDR) in cancer: total synthesis and discovery of potent MDR reversal agents

• Main Authors: Senling Feng (Author), Huifang Zhou (Author), Deyan Wu (Author), Dechong Zheng (Author), Biao Qu (Author), Ruiming Liu (Author), Chen Zhang (Author), Zhe Li (Author), Ying Xie (Author), Hai-Bin Luo (Author)
• Format: Book
• Published: Elsevier, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Our recent studies demonstrated that the natural product nobiletin (NOB) served as a promising multidrug resistance (MDR) reversal agent and improved the effectiveness of cancer chemotherapy in vitro. However, low aqueous solubility and difficulty in total synthesis limited its application as a ther...