Design of drug-like hepsin inhibitors against prostate cancer and kidney stones

• Main Authors: Vincent Blay (Author), Mu-Chun Li (Author), Sunita P. Ho (Author), Mashall L. Stoller (Author), Hsing-Pang Hsieh (Author), Douglas R. Houston (Author)
• Format: Book
• Published: Elsevier, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepsin, a transmembrane serine protease abundant in renal endothelial cells, is a promising therapeutic target against several cancers, particularly prostate cancer. It is involved in the release and polymerization of uromodulin in the urine, which plays a role in kidney stone formation. In this wor...