Mechanochemical Formation of Racemic Praziquantel Hemihydrate with Improved Biopharmaceutical Properties

• Main Authors: Debora Zanolla (Author), Dritan Hasa (Author), Mihails Arhangelskis (Author), Gabriela Schneider-Rauber (Author), Michele R. Chierotti (Author), Jennifer Keiser (Author), Dario Voinovich (Author), William Jones (Author), Beatrice Perissutti (Author)
• Format: Book
• Published: MDPI AG, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Praziquantel (PZQ) is the first-line drug used against schistosomiasis, one of the most common parasitic diseases in the world. A series of crystalline structures including two new polymorphs of the pure drug and a series of cocrystals of PZQ have been discovered and deposited in the Cambridge Struc...