BRD4 inhibitor reduces exhaustion and blocks terminal differentiation in CAR-T cells by modulating BATF and EGR1

• Main Authors: Songnan Sui (Author), Mengjun Zhong (Author), Shuxin Zhong (Author), Xueting Peng (Author), Lipeng Mao (Author), Cunte Chen (Author), Chengwu Zeng (Author), Oscar Junhong Luo (Author), Yangqiu Li (Author)
• Format: Book
• Published: BMC, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Exhaustion is a key factor that influences the efficacy of chimeric antigen receptor T (CAR-T) cells. Our previous study demonstrated that a bromodomain protein 4 (BRD4) inhibitor can revise the phenotype and function of exhausted T cells from leukemia patients. This study aims t...