Usher syndrome type 1-associated gene, pcdh15b, is required for photoreceptor structural integrity in zebrafish

• Κύριοι συγγραφείς: Amanda Miles (Συγγραφέας), Clarke Blair (Συγγραφέας), Andrew Emili (Συγγραφέας), Vincent Tropepe (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: The Company of Biologists, 2021-12-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Blindness associated with Usher syndrome type 1 (USH1) is typically characterized as rod photoreceptor degeneration, followed by secondary loss of cones. The mechanisms leading to blindness are unknown because most genetic mouse models only recapitulate auditory defects. We generated zebrafish mutan...