A simian-adenovirus-vectored rabies vaccine suitable for thermostabilisation and clinical development for low-cost single-dose pre-exposure prophylaxis.

• Автори: Chuan Wang (Автор), Pawan Dulal (Автор), Xiangyang Zhou (Автор), Zhiquan Xiang (Автор), Hooman Goharriz (Автор), Ashley Banyard (Автор), Nicky Green (Автор), Livia Brunner (Автор), Roland Ventura (Автор), Nicolas Collin (Автор), Simon J Draper (Автор), Adrian V S Hill (Автор), Rebecca Ashfield (Автор), Anthony R Fooks (Автор), Hildegund C Ertl (Автор), Alexander D Douglas (Автор)
• Формат: Книга
• Опубліковано: Public Library of Science (PLoS), 2018-10-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

BACKGROUND:Estimates of current global rabies mortality range from 26,000 to 59,000 deaths per annum. Although pre-exposure prophylaxis using inactivated rabies virus vaccines (IRVs) is effective, it requires two to three doses and is regarded as being too expensive and impractical for inclusion in...