A simian-adenovirus-vectored rabies vaccine suitable for thermostabilisation and clinical development for low-cost single-dose pre-exposure prophylaxis.

• Main Authors: Chuan Wang (Author), Pawan Dulal (Author), Xiangyang Zhou (Author), Zhiquan Xiang (Author), Hooman Goharriz (Author), Ashley Banyard (Author), Nicky Green (Author), Livia Brunner (Author), Roland Ventura (Author), Nicolas Collin (Author), Simon J Draper (Author), Adrian V S Hill (Author), Rebecca Ashfield (Author), Anthony R Fooks (Author), Hildegund C Ertl (Author), Alexander D Douglas (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Estimates of current global rabies mortality range from 26,000 to 59,000 deaths per annum. Although pre-exposure prophylaxis using inactivated rabies virus vaccines (IRVs) is effective, it requires two to three doses and is regarded as being too expensive and impractical for inclusion in...