Targeted Delivery of the HLA-B∗27-Binding Peptide into the Endoplasmic Reticulum Suppresses the IL-23/IL-17 Axis of Immune Cells in Spondylarthritis

• Päätekijät: Hui-Chun Yu (Tekijä), Kuang-Yung Huang (Tekijä), Ming-Chi Lu (Tekijä), Hsien-Lu Huang (Tekijä), Su-Qin Liu (Tekijä), Ning-Sheng Lai (Tekijä), Hsien-Bin Huang (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Hindawi Limited, 2017-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Ankylosing spondylitis (AS) is highly associated with the expression of human leukocyte antigen-B27 (HLA-B∗27). HLA-B∗27 heavy chain (B27-HC) has an intrinsic propensity to fold slowly, leading to the accumulation of the misfolded B27-HC in the endoplasmic reticulum (ER) and formation of the HLA-B∗2...