Depletion of UDP-Glucose and UDP-Galactose Using a Degron System Leads to Growth Cessation of Leishmania major.

• Main Authors: Sebastian Damerow (Author), Carolin Hoppe (Author), Giulia Bandini (Author), Patricia Zarnovican (Author), Falk F R Buettner (Author), Carsten G K Lüder (Author), Michael A J Ferguson (Author), Françoise H Routier (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Interconversion of UDP-glucose (UDP-Glc) and UDP-galactose (UDP-Gal) by the UDP-Glc 4´-epimerase intimately connects the biosynthesis of these two nucleotide sugars. Their de novo biosynthesis involves transformation of glucose-6-phosphate into glucose-1-phosphate by the phosphoglucomutase and subse...