Traditional Herbal Medicine-Derived Sulforaphene LFS-01 Reverses Colitis in Mice by Selectively Altering the Gut Microbiota and Promoting Intestinal Gamma-Delta T Cells

• Main Authors: Ming Li (Author), Jiali Gao (Author), Yan Tang (Author), Meishuo Liu (Author), Sijin Wu (Author), Kunli Qu (Author), Xiangyu Long (Author), Huajun Li (Author), Min Liu (Author), Yinhui Liu (Author), Jieli Yuan (Author), Lei Mao (Author), Yu Liu (Author), Xiliang Zheng (Author), Erkang Wang (Author), Jin Wang (Author), Yongliang Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sulforaphene (LFS-01) is a natural compound derived from traditional herbal medicine. Here, we show that oral administration of LFS-01 is able to dramatically alter the skewed gut microbiota and reverse colitis in model mice associated with an increase of intestinal γδT cells. Through 16S rDNA seque...