Protective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation

• Main Authors: Chi-Han Huang (Author), Shu-Chi Wang (Author), I-Chen Chen (Author), Yi-Ting Chen (Author), Po-Len Liu (Author), Shih-Hua Fang (Author), Shu-Pin Huang (Author), Hsin-Chih Yeh (Author), Ching-Chih Liu (Author), Po-Yen Lee (Author), Tzu-Chieh Lin (Author), Wei-Chung Cheng (Author), Chia-Cheng Su (Author), Hsin-En Wu (Author), Yuan-Ru Chen (Author), Chia-Yang Li (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Piplartine (or Piperlongumine) is a natural alkaloid isolated from <i>Piper longum</i> L., which has been proposed to exhibit various biological properties such as anti-inflammatory effects; however, the effect of piplartine on sepsis has not been examined. This study was performed to ex...