Identification of the leptin receptor sequences crucial for the STAT3-Independent control of metabolism

• Main Authors: Tammy M. Barnes (Author), Kimi Shah (Author), Margaret B. Allison (Author), Gabrielle K. Steinl (Author), Desiree Gordian (Author), Paul V. Sabatini (Author), Abigail J. Tomlinson (Author), Wenwen Cheng (Author), Justin C. Jones (Author), Qing Zhu (Author), Chelsea Faber (Author), Martin G. Myers, Jr (Author)
• Format: Book
• Published: Elsevier, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Leptin acts via its receptor, LepRb, on specialized neurons in the brain to modulate energy balance and glucose homeostasis. LepRb→STAT3 signaling plays a crucial role in leptin action, but LepRb also mediates an additional as-yet-unidentified signal (Signal 2) that is important for lept...