Development of a novel BRCAness score that predicts response to PARP inhibitors

• Main Authors: Masanori Oshi (Author), Shipra Gandhi (Author), Rongrong Wu (Author), Mariko Asaoka (Author), Li Yan (Author), Akimitsu Yamada (Author), Shinya Yamamoto (Author), Kazutaka Narui (Author), Takashi Chishima (Author), Takashi Ishikawa (Author), Itaru Endo (Author), Kazuaki Takabe (Author)
• Format: Book
• Published: BMC, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background BRCAness is a characteristic feature of homologous recombination deficiency (HRD) mimicking BRCA gene mutation in breast cancer. We hypothesized that a measure to quantify BRCAness that causes synthetic lethality in BRCA mutated tumors will identify responders to PARP inhibitors....