Organic anion transporters also mediate the drug-drug interaction between imipenem and cilastatin

• Main Authors: Yanna Zhu (Author), Xiaokui Huo (Author), Changyuan Wang (Author), Qiang Meng (Author), Zhihao Liu (Author), Huijun Sun (Author), Aiping Tan (Author), Xiaodong Ma (Author), Jinyong Peng (Author), Kexin Liu (Author)
• Format: Book
• Published: Elsevier, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to clarify that organic anion transporters (OATs) mediate the drug-drug interaction (DDI) between imipenem and cilastatin. After co-administration with imipenem, the plasma concentrations and the plasma concentration-time curve (AUC) of cilastatin were significantly increased, while...