Acute Hypokalemia May Not Be an Effective Way to Sensitize the In Situ Canine Heart for Sparfloxacin-Induced Long QT Syndrome

• Hoofdauteurs: Katsuyoshi Chiba (Auteur), Atsushi Sugiyama (Auteur), Kazuo Watanabe (Auteur), Kiyoshi Takasuna (Auteur), Keitaro Hashimoto (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2006-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract.: Extents of the sparfloxacin (3 - 10 mg/kg, i.v.)-induced QT interval prolongation under normokalemic and hypokalemic conditions were assessed in halothane-anesthetized beagle dogs (n = 5). The hypokalemic condition was induced by an oral administration of furosemide (200 mg/kg per day) fo...