Repeatable, Inducible Micro-RNA-Based Technology Tightly Controls Liver Transgene Expression

• Main Authors: Iulian I Oprea (Author), Joana R Viola (Author), Pedro M D Moreno (Author), Oscar E Simonson (Author), Sergey Rodin (Author), Nathalie Teller (Author), Karl Tryggvason (Author), Karin E Lundin (Author), Leonard Girnita (Author), Carl Inge Edvard Smith (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inducible systems for gene expression emerge as a new class of artificial vectors offering temporal and spatial exogenous control of gene expression. However, most inducible systems are less efficient in vivo and lack the target-organ specificity. In the present study, we have developed and optimize...